Abstract

Parental depression is associated with offspring depression and sleep problems are prospectively associated with the development of depression. However, little work has examined sleep problems in the offspring of depressed parents and whether these problems partially account for the association between parent and offspring depression. This longitudinal study examined the indirect effect of sleep problems on the association between parent psychopathology and offspring depression in a sample of 10,953 10 to 12-year-old children participating in the Adolescent Brain and Cognitive Development (ABCD) study. Controlling for age, sex, and other forms of parent psychopathology, we found significant indirect effects of parent to offspring depression through parent and youth reports of youth insomnia and hypersomnia. We also found indirect effects of parent history of anxiety and drug use problems to offspring depression through insomnia, and indirect effects of parent history of anxiety, drug use problems, and alcohol use problems to offspring depression through hypersomnia. Our findings show that sleep may be a mechanism of the transmission of parent depression, anxiety, drug use problems, and alcohol use problems to offspring depression. Mitigating sleep problems represents a potential avenue for preventative interventions in youth with a heightened susceptibility to depression.

Abstract

Despite frequent reliance on teacher and parent ratings of children’s behavior for multi-informant assessment, agreement between teachers’ and parents’ ratings is low. This study examined the predictive utility of teacher and parent ratings for children’s self-regulatory outcomes (i.e., executive function, continuous performance task) in four studies. Study 1 included 163 children ranging from 31 to 84 months of age (M = 55.58 months, SD = 8.43). Study 2 included 1,088 children ranging from 48 to 63 months of age (M = 55.15, SD = 3.65). Study 3 included 246 bilingual Spanish-speaking children ranging from 40 to 72 months of age (M = 56.66, SD = 6.06). Study 4 included 280 children ranging from 38 to 75 months of age (M = 55.92, SD = 4.16). Across studies, parents and teachers rated children’s externalizing behaviors on the Conners’ Rating Scale, the Strength and Weaknesses of ADHD-Symptoms and Normal Behavior Scale, or both; children completed a variety of performance-based self-regulation tasks. The strength of associations of parent and teacher ratings with self-regulatory outcomes was compared, and regression analyses determined the unique and overlapping variance accounted for by different raters. Teachers’ ratings had larger associations with self-regulation than did parents’ ratings across outcomes and studies–except for two instances in Study 4 where the associations for teachers’ and parents’ ratings were equal. These findings indicate that teachers supply more useful information than parents, possibly because teachers have better-informed expectations of children’s behavior, and they raise questions about the utility of multi-informant assessment, at least with preschool children.

Abstract

The aim of this study is to investigate the impact of using probiotics with strains related to dopamine and gamma-aminobutyric acid production on clinical features of autism spectrum disorder (ASD) and/or attention deficit/hyperactivity disorder (ADHD). This randomized, controlled trial involved 38 children with ADHD and 42 children with ASD, aged 5–16 years, who received probiotics (Lactiplantibacillus plantarum and Levilactobacillus brevis 109/cfu/daily) or placebo for 12 weeks. Parent-reported symptoms were assessed using Conners' 3rd-Ed and the Social Responsiveness Scale Test, 2nd-Ed (SRS-2), and children completed the Conners Continuous Performance Test, 3rd-Ed (CPT 3) or Conners Kiddie CPT, 2nd-Ed (K-CPT 2). Executive functions, quality of life and sleep patterns were also parent-assessed. Intention-to-treat analyses, controlling for sociodemographic and nutritional covariates, revealed no significant inter-group differences in parent-reported or neuropsychological data after the probiotic intervention. However, age-stratified analyses showed improved hyperactivity-impulsivity symptoms in younger children with ASD (Cohen’s d = 1.245) and ADHD (Cohen’s d = 0.692). Intra-group analyses supported these findings in the aforementioned age and intervention group for both diagnoses. An improvement in impulsivity for children with ASD was also observed in the intra-group analysis of the CPT commissions scores (probiotic: p = 0.001, Cohen’s d = -1.216; placebo: p = 0.013, Cohen’s d = -0.721). A better comfort score (quality of life) was shown in children with ASD (probiotic: p = 0.010, Cohen’s d = 0.722; placebo: p = 0.099, Cohen’s d = 0.456). The probiotics used, may improve hyperactivity-impulsivity in children with ASD or/and ADHD and quality of life in children with ASD. Further research is warranted to explore probiotics as an adjunctive therapeutic intervention for NDs.

Trial registration: clinicaltrials.gov Identifier: NCT05167110.

Abstract

To prevent young children’s injuries, studies have considered both child (e.g., temperament, age, sex) and parent factors (e.g., parental supervision and style, attachment) associated with risk-taking behaviors. Building on risk-taking theory literature, Jonas and Kochanska (Jonas & Kochanska, Journal of Abnormal Child Psychology 46:1573–1583, 2018) adapted the dual systems model (Steinberg, Developmental Review 28:78–106, 2008) to children and suggested that risk-taking propensity arises from an imbalance between the overactivation of the child’s socioemotional system (sensation seeking or traits of surgency) and the lower cognitive control system (lack of self-regulation or of effortful control). However, from an intergenerational transmission perspective, it is relevant to consider the role both parents’ and the children’s socioemotional and cognitive control systems have on a child’s risk-taking behaviors. The current longitudinal study is the first to examines sensation seeking and lack of self-regulation in parents in addition to the child’s surgency-effortful control imbalance to understand the child’s risk-taking behaviors. The sample comprised 177 two-parent families (89 boys) observed at two time points (child age ranges: 12–18 months and 24–30 months). Both parents provided sociodemographic information and completed self-reported questionnaires on sensation seeking and self-regulation, child’s temperament and risk-taking behaviors. Results showed that fathers’ higher sensation-seeking and mothers’ lack of self-regulation were associated with higher children’s risk-taking behaviors. After controlling for these parent factors and child sex, child surgency-effortful imbalance was strongly associated with higher children’s risk-taking behaviors. An adapted dual systems model including both parents (sensation seeking and self-regulation) and children (surgency-effortful imbalance) seems a promising avenue to a fuller understanding of children’s risk-taking behaviors.

Abstract

Recently, an association between cognitive disengagement syndrome (CDS), formerly sluggish cognitive tempo, and autism has been documented, but it is not known if the association is due to overlapping autism and CDS traits or if CDS is empirically distinct from autism. Mothers rated 2,209 children 4–17 years (1,177 with autism, 725 with ADHD-Combined type, and 307 with ADHD-Inattentive type) on the Pediatric Behavior Scale. Factor analysis of the Pediatric Behavior Scale items indicated that CDS and autism traits are empirically distinct from each other without cross-loading and are distinct from eight other factors (attention deficit, impulsivity, hyperactivity, oppositional behavior, irritability/anger, conduct problems, depression, and anxiety). CDS total scores were significantly higher in the autism + ADHD-Inattentive and autism + ADHD-Combined groups than in the autism, ADHD-Combined, and ADHD-Inattentive only groups with a nonsignificant difference between the latter three groups. CDS and autism are empirically distinct from each other and from other psychopathology dimensions. Overlapping traits do not explain the association between autism and CDS. Autism in combination with ADHD-Combined or ADHD-Inattentive increases the likelihood of CDS relative to youth who have autism, ADHD-Combined, or ADHD-Inattentive only. Because of the known associations between autism, CDS, and ADHD, both autism and ADHD must be assessed in CDS research and clinically to better understand and explain research findings and provide targeted clinical intervention.

Abstract

The error-related negativity (ERN) has been called a putative neural marker of anxiety risk in children, with smaller ERN amplitudes denoting greater risk in early childhood. Children of anxious mothers are at elevated risk for anxiety problems compared to children of non-anxious mothers. Still unknown is whether discrete maternal symptoms interact with child ERN to predict different forms of child anxiety risk, knowledge of which could increase our understanding of the specificity of known conditions and pathways for transgenerational effects. Targeting two of the most prevalent forms of anxiety problems across children and adults, we tested whether maternal generalized anxiety disorder (GAD) and social phobia (SP) symptoms when children were 3 years old interacted with child ERN at age 4 years to predict child symptoms of overanxiousness and separation anxiety at age 5 years. We found that greater maternal SP, but not GAD, symptoms along with smaller (i.e., less negative) child ERN predicted more separation anxiety and overanxious symptoms in children, suggesting some specificity in prediction but less specificity in outcomes regarding the transmission of anxiety risk from mothers to offspring.

Abstract

Obsessive-compulsive disorder (OCD) and anxiety disorders are early-onset mental disorders characterized by selective attention and strong emotional reactions. Attentional bias has been proposed to play a role in the development, onset, and maintenance of the disorders, but few studies have included youth with mental disorders, and no study has included more than one clinical group, making it unclear whether biased attention is disorder-specific or transdiagnostic in nature. In the present study, 65 youths with OCD (M_age = 13.6 [2.4], 57% girls), 52 youths with anxiety disorders (M_age = 14.5 [2.6] 83% girls), and 45 youths without a psychiatric disorder (M_age = 13.9 [3.1], 67% girls) completed a modified dot-probe task that included threat, incompleteness, and disgust cues. Contrary to our hypotheses, no group exhibited any attentional bias to any emotional cue, no group differences were present, and individual differences in attentional bias were not associated with individual differences in any symptom type. Disgust cues produced slower response times compared to the other emotional cues, but this effect was consistent across all type of trials and present in all three groups. In this study, no support for biased attention in treatment-seeking youth with OCD or anxiety disorders was found, which is in line with recent findings in adults using the dot-probe task. As attentional processes are clearly implicated in the clinical manifestation of these disorders, future research should try to better operationalize and measure relevant processes.